GRACE score predicts systemic inflammation in patients with acute coronary syndrome

Abstract Background New insights of inflammation CANTOS (1) and COLCOT (2) demonstrated the importance blocking in CAD for major outcomes, but only patients with systemic inflammation. The GRACE score is a readily available tool that uses variety items none related to per se. Many studies have emphasised inflammation, however, most markers are not clinic setting. Purpose Determine if may reflect measured by WBC, hsCRP, albumin, IL-1β, IL-6, IL-8, IL-10. Methods 77 NSTEMI/STEMI were enrolled at time hospital admission, all had <24 h initial symptom, >18 years old received no therapy before samples obtained. Patients pregnancy or postpartum period, infectious, autoimmune, hepatic, neoplastic diseases excluded; as well current previous dialysis, transplant, episodes acute chronic heart failure, ACS. hsCRP troponin I, IL-10, measured. Low rank regression splines, predefined analysis IL-1β + hsCRP/ IL-6 / vs was performed, adjusted sex, type ACS, hypertension, diabetes. A p<0,05 set significant. Results significantly correlated (ρ=0.352), (ρ=0.465), IL-8 (ρ=0.325), IL-10 (ρ=0.31), WBC (ρ=0.428), (ρ=0.46), albumin (ρ=−0.538). In low splines positive correlation (F=45.52 p<0.001; fig 1B) inflection scores >150. also significant (F=21.54 1C). linear (F=7.32; F=8.36; F=5.32 p<0.02; respectively; 1 D,E,G); non-linear association (F=6.54 p=0.003; 1F). Finally, negative relationship (F=29.68 fIg 1A), point GRACE>125. Analysis log-IL-1 β log-hsCRP (df= 2.07 4.9, F=12.84 23.23; 2A) log- log-IL-6 2.23 6.53, F= 12.98 16.87, 2B) showed presence proportional increase variables correlates higher scores. Lastly, F=18.18 2.8 p<0.001 0.07, respectively (fig 2C). Conclusion Our data suggest various cytokines could be inferred non directly, IL-1, This open new avenues personalized cardiology based practical tools, possibly identifying get benefit anti-cytokine anti-inflammatory interventions. Funding Acknowledgement Type funding sources: Public hospital(s). Main source(s): Instituto Nacional de Cardiología Ignacio Chávez Figure A. splinesFigure B.